rheology in pharmacy


doi: Horter D, Dressman JB (2001) Influence of physicochemical properties on dissolution of drugs in the gastrointestinal tract. Barry BW, Meyer MC (1979a) The rheological properties of carbopol gels. Rheol Acta 39(5):444–451. J Rheol 56(5):1279. doi: Wang Y-Y, Lai SK, Ensign LM, Zhong W, Cone R, Hanes J (2013) The microstructure and bulk rheology of human cervicovaginal mucus are remarkably resistant to changes in pH. J Nonnewton Fluid Mech 11(3–4):301–316. Rheology as a tool to; •Shorten the time for formulation development •Optimise processing at its various stages •Enhance the performance/quality of products •Predict mechanical and thermal product stability (cyclic testing) •Development of innovative products • Gel instead of … WHITHER RHEOLOGY IN PHARMACY? Rheology is therefore crucially important as it will directly affect the way a drug is formulated and developed, the quality of the raw and finished product, the drug efficacy, the way a patient adheres to the prescribed drug, and the overall healthcare cost. Polym Eng Sci 11(2):174–176. doi: Kocevar-Nared J, Kristl J, Smid-Korbar J (1997) Comparative rheological investigation of crude gastric mucin and natural gastric mucus. Sex Transm Dis 30(3):257–261. Vlachopoulos J, Strutt D (2003) The role of rheology in polymer extrusion. Eur Polym J 46(2):324–335. Am J Respir Crit Care Med 178(10):1033–1039. They have to learn what to measure, how to measure, and what to do with the data. This site uses Akismet to reduce spam. [wp_ad_camp_1]. Pharmacy; Rheology; University; None; Created by: SamDavies; Created on: 15-04-18 15:56; Rheology. Carbohydr Polym 91(2):529–536. Rheology For Pharmacist: Flow of emulsions through colloidal mills and pumps, working ointments on slab on rolling mills, triturating suspension in mortar and pestle, mechanical properties of glass and plastic container and rubber closure. * WARBURTON, B. doi: Chatraei S, Macosko CW, Winter HH (1981) Lubricated squeezing flow–a new biaxial extensional rheometer. Food Hydrocolloids 24(2–3):184–192. Rheol Acta 52(5):413–423. Email- vijaywaghulkar@gmail.com Food Hydrocolloids 25(5):1201–1209. Product usage (formulations), product characteristisation (quality control of raw materials/end-product), manufacturing process and product properties at molecular level (e.g. Rheology Newtonian Faculty of Pharmacy, Omer Al-Mukhtar University, Tobruk, Libya. Am J Physiol 293(5):L1240–L1249. Semisolid products are the most difficult materials to characterize rheologically because they combine both liquid and solid properties within the same material. Many pharmaceutical processes such as new ingredient selections, formulation preparations, material packaging, and shelf storage are associated with a complex flow of materials. KW - Pharmacy doi: Bain MK, Maity D, Bhowmick B, Mondal D, Mollick MMR, Sarkar G, Bhowmik M, Rana D, Chattopadhyay D (2013) Effect of PEG–salt mixture on the gelation temperature and morphology of MC gel for sustained delivery of drug. Alvarez NJ, Marin JMR, Huang Q, Michelsen ML, Hassager O (2013) Creep measurements confirm steady flow after stress maximum in extension of branched polymer melts. F=nG G F The term ―rheology,‖ from the Greek rheo (―to flow‖) and logos (―science‖), was suggested by Bingham and Crawford (as reported by Fischer1) to … Aho J, Rolon-Garrido VH, Syrjala S, Wagner MH (2010) Measurement technique and data analysis of extensional viscosity for polymer melts by Sentmanat extensional rheometer (SER). J Rheol 55(4):875–900. Rheology is science which treats the deformation and flow of materials. Food Hydrocolloids 27(1):80–90. Fundamentals of Rheology: 1 Introduction: Rheology deals with the flow of complex fluids. Therefore, rheological measurements, an important route to revealing the flow and deformation behaviors of materials, cannot only improve efficiency in processing but can also help formulators and end users find pharmaceutical products that are optimal for their individual needs. All normal or Newtonian fluids (air, water, oil, honey) follow the same scientific laws. Several classes may be … J Food Eng 70(4):538–545. Ober TJ, Haward SJ, Pipe CJ, Soulages J, McKinley GH (2013) Microfluidic extensional rheometry using a hyperbolic contraction geometry. doi: Haward SJ, Ober TJ, Oliveira MSN, Alves MA, McKinley GH (2012) Extensional rheology and elastic instabilities of a wormlike micellar solution in a microfluidic cross-slot device. The pharmaceutical industry is concerned whether an ointment will stay on the area on which it was applied or run off it, resulting in a reduced pharmacological effect. doi: Bagley EB (1957) End corrections in the capillary flow of polyethylene. Learn how your comment data is processed. Classical theory of elasticity treats the elastic solid which is accordant to Hooke’s law [1]. Particularly gels and non-Newtonian fluids, which exhibit complex flow behavior, are … Liquids that obey Newton’s law of flow are called as Newtonianfluids. In: Lobo HB, Bonilla JV (eds) Handbook in plastics analysis. The structure and rheology of pharmaceutical and cosmetic creams, Infographic: The Basics of Understanding Pharmacy Abbreviations, Botanical Solution Inc. (BSI) Secures $3.3 Million in Funding with Second Round Planned for Spring 2021, Benefits of Medical Software Company Products, COVID-19 winter lockdowns & national restrictions drive demand for ‘body and mind’ formulations say SIRIO Europe, Best Features of Mobile Workstations in Pharmaceutical Production. [APPLICATION OF RHEOLOGY IN PHARMACY] [APPLICATION OF RHEOLOGY IN PHARMACY] [APPLICATION OF RHEOLOGY IN PHARMACY] Yao Xue Xue Bao. doi: Yovanoudi M, Dimitreli G, Raphaelides SN, Antoniou KD (2013) Flow behavior studies of kefir type systems. Polym Eng Sci 12(1):64. doi: Cone RA (2009) Barrier properties of mucus. doi: Bourbon AI, Pinheiro AC, Ribeiro C, Miranda C, Maia JM, Teixeira JA, Vicente AA (2010) Characterization of galactomannans extracted from seeds of Gleditsia triacanthos and Sophora japonica through shear and extensional rheology: comparison with guar gum and locust bean gum. Rheol Acta 49(4):359–370. Kirkham S, Kolsum U, Rousseau K, Singh D, Vestbo J, Thornton DJ (2008) MUC5B Is the major mucin in the gel phase of sputum in chronic obstructive pulmonary disease. 1963 Jun;10:376-88 CONTD. The liquid droplets (the disperse phase) are dispersed in a liquid medium (the continuous phase). Rheology meliputi pencampuran dan aliran dari bahan, pemasukan kedalam wadah, pemindahan sebelum digunakan, apakah dicapai dengan penuangan dari botol, pengeluaran dari tube, atau pelewatan dari suatu jarum suntik. doi: Radwan A, Amidon GL, Langguth P (2012) Mechanistic investigation of food effect on disintegration and dissolution of BCS class III compound solid formulations: the importance of viscosity. Rheology: Concepts, Methods, and Applications, Second Edition is a tool for chemists and chemical engineers to solve many practical problems. Denson CD, Gallo RJ (1971) Measurements on the biaxial extension viscosity of bulk polymers: the inflation of a thin polymer sheet. Biopolymers 101(3):287–305. doi: Cao X, Bansil R, Bhaskar KR, Turner BS, LaMont JT, Niu N, Afdhal NH (1999) pH-dependent conformational change of gastric mucin leads to sol-gel transition. 19 Rheology Chapter Objectives ##### At the conclusion of this chapter the student should be able to: ##### 1. [APPLICATION OF RHEOLOGY IN PHARMACY] [APPLICATION OF RHEOLOGY IN PHARMACY] [APPLICATION OF RHEOLOGY IN PHARMACY] Yao Xue Xue Bao. ##### 2. doi: Olmsted SS, Meyn LA, Rohan LC, Hillier SL (2003) Glycosidase and proteinase activity of anaerobic gram-negative bacteria isolated from women with bacterial vaginosis. Solids are said to have an ‘elastic’ response, and can resist This chapter introduces the basics of both shear and extensional rheology, together with the common measurement techniques and their practical applications. On the other hand, there are also fluids that do not follow the Newtonian flow laws. Macromol Rapid Commun Macromol Rapid Commun 35(8):780–786. Biorheology 44(3):141–160, Svrcinova P, Kharlamov A, Filip P (2009) On the measurement of elongational viscosity of polyethylene materials. The viscosity of a liquid is a measure of its resistance to flow. Viscosity. Flow modeling. doi: Morrison FA (2001) Understanding rheology. Particularly gels and non-Newtonian fluids, which exhibit complex flow behavior, are frequently encountered in pharmaceutical engineering and manufacturing, or when dealing with various in vivo fluids. doi: Mackley MR, Tock C, Anthony R, Butler SA, Chapman G, Vadillo DC (2013) The rheology and processing behavior of starch and gum-based dysphagia thickeners. Particularly gels and non-Newtonian fluids, which exhibit complex flow behavior, are frequently encountered in pharmaceutical engineering and manufacturing, or when dealing with various in vivo fluids. 1 Venerus DC, Kompani M, Bernstein B (2000) Equibiaxial extensional flow of polymer melts via lubricated squeezing flow. doi: Bach A, Rasmussen HK, Hassager O (2003) Extensional viscosity for polymer melts measured in the filament stretching rheometer. 1963 Jul;10:442-9 CONTD. J Food Sci 76(1):E15–E22. PMID: 14070621 No abstract available. Kluwer Academic, Dordrecht. Rheology pdf 1. Int J Pharm 2(1):27–40. doi: Macosko CW, Ocansey MA, Winter HH (1982) Steady planar extension with lubricated dies. Expert Opin Drug Delivery 8(10):1309–1322. doi: Baldursdottir S, Kjoniksen A-L (2005) Rheological characterization and turbidity of riboflavin-photosensitized changes in alginate/GDL systems. [Article in Chinese] Authors M T HO, S L CHANG. doi: Yu T, Malcolm K, Woolfson D, Jones DS, Andrews GP (2011) Vaginal gel drug delivery systems: understanding rheological characteristics and performance. Polymer 45(9):2959–2966. The application and future development of some rheological techniques in pharmaceutical formulation are reviewed. Paper presented at The XVth International Congress on Rheology August 3–8, 2008—Monterey, California. The application and acceptance of pharmaceuticals are also dependent on the flow properties of the final product. doi: Pipe CJ, Majmudar TS, McKinley GH (2008) High shear rate viscometry. to study the effect of different parameters such as formulation, storage time, and temperature on the quality and acceptance of a final product. Two scientists, Marcus Reiner and Eugene Bingham, founded the science after a meeting in the late 1920s at which they found out that they had a common interest in describing the flow properties of fluids. J Appl Phys 28(5):624–627. Biomaterials 18(9):677–681. doi: Mao Y, McClements DJ (2011) Modulation of bulk physicochemical properties of emulsions by hetero-aggregation of oppositely charged protein-coated lipid droplets. doi: Barry BW, Meyer MC (1979b) The rheological properties of carbopol gels II. Edited by B. Warburton. Newtonian Flow •Newton was the first to study the flow properties of liquids in quantitative terms. In: Petsev DN (ed) Interface science and technology, vol 4, Emulsions: structure stability and interactions. doi: Analytical Techniques in the Pharmaceutical Sciences, http://www.tainstruments.com/pdf/literature/APN002_V2_ARES_EVF_to_measure_elongation_viscosity.pdf, http://dx.doi.org/10.1016/j.colsurfa.2006.11.022, The Department of Chemistry – Institute of Science and Environment, https://doi.org/10.1007/978-1-4939-4029-5_23, Advances in Delivery Science and Technology. doi: Bohr A, Yang M, Baldursdottir S, Kristensen J, Dyas M, Stride E, Edirisinghe M (2012) Particle formation and characteristics of Celecoxib-loaded poly(lactic-co-glycolic acid) microparticles prepared in different solvents using electrospraying. * WHITHER RHEOLOGY IN PHARMACY? Am J Physiol 261(5):G827–G832. Int J Pharm 355(1–2):93–99. Fluids are different from solids, because fluids continuously deform when there is an applied stress, as shown in figure 1(b), while solids deform and then stop, as shown in figure 1(a). Rheol Acta 52(6):529–546. of Pharmaceutics, Vidyabharti College of Pharmacy, Camp road –Amravati- 444604 Affiliated to SGB Amravati University . Your email address will not be published. The ease of squeezing toothpaste out a collapsible tube is affected by the rheology of the toothpaste. Royal Society of Chemistry, Cambridge, UK. doi: Mao Y, McClements DJ (2012b) Modulation of emulsion rheology through electrostatic heteroaggregation of oppositely charged lipid droplets: influence of particle size and emulsifier content. doi: Nelson B (2003) Capillary rheometry. J Rheol 40(4):473–481. Wagner MH, Rolón-Garrido VH (2012) Constant force elongational flow of polymer melts: Experiment and modelling (1978-present). Am J Physiol 280(5):G922–G929. The resistance of the fluid to flow or movement. Significant advances in rheology of pharmaceutical and allied materials since 1965 are covered in a review of 292 references. Son WK, Youk JH, Lee TS, Park WH (2004) The effects of solution properties and polyelectrolyte on electrospinning of ultrafine poly(ethylene oxide) fibers. Introducon to Rheology D. Vader, H.Wyss Weitzlab group meeng tutorial -10x10-3-5 0 5 10 strain 0 2 4 6 8 10 12 time [s] Munstedt H, Stary Z (2013) Steady states in extensional flow of strain hardening polymer melts and the uncertainties of their determination. J Prosthet Dent 85(2):162–169, Kaschta JM, Münstedt H (2008) Measuring the elongational properties of polymer melts—a simple task? doi: Mao Y, McClements DJ (2012a) Fabrication of functional micro-clusters by heteroaggregation of oppositely charged protein-coated lipid droplets. Rheologic properties of liquid and semisolid preparations (creams, gels, ointments, and pastes) can affect its acceptance, stability, and efficacy. stability) 4 of 65. Rheology is the science of flow and deformation of matter. Rheological properties are studied with rheometry. Eur J Pharm Biopharm 87(2):227–35. Cite as. © 2020 Springer Nature Switzerland AG. Not affiliated Why is rheology important in Pharmacy? Experimental analysis. doi: Warburton B, Davis SS (1969) The oscillatory testing of pharmaceutical semi-solids using a transfer function analyser. J Nanomater 2013:924947. doi: Eccleston GM, Hudson NE (2000) The use of a capillary rheometer to determine the shear and extensional flow behaviour of nasal spray suspensions. Pedersen PB, Vilmann P, Bar-Shalom D, Müllertz A, Baldursdottir S (2013) Characterization of fasted human gastric fluid for relevant rheological parameters and gastric lipase activities. Scand J Gastroenterol Suppl 93:101–113. Define rheology, provide examples of fluid pharmaceutical products exhibiting various rheologic behaviors, and describe the application of rheology in the pharmaceutical sciences and practice of … doi: Bhaskar KR, Gong D, Bansil R, Pajevic S, Hamilton JA, Turner BS, LaMont JT (1991) Profound increase in viscosity and aggregation of pig gastric mucin at low pH. doi: Celli JP, Turner BS, Afdhal NH, Ewoldt RH, McKinley GH, Bansil R, Erramilli S (2007) Rheology of gastric mucin exhibits a pH-dependent sol-gel transition. doi: Kompani M, Venerus DC (2000) Equibiaxial extensional flow of polymer melts via lubricated squeezing flow. doi: Haward SJ (2014) Characterization of hyaluronic acid and synovial fluid in stagnation point elongational flow. All normal or Newtonian fluids (air, water, oil, honey) follow the same scientific laws. Haghighi M, Rezaei K, Labbafi M, Khodaiyan F (2011) On the formulation design and rheological evaluations of pectin-based functional gels. Examples of the use of rheological techniques in the pharmaceutical field, as well as other closely related fields such as food and polymer science, are also given. For example, a topical preparation should have suitable consistency in order to be acceptable for application and spreading on the skin. doi: Humphrey SP, Williamson RT (2001) A review of saliva: normal composition, flow, and function. The rheology has a lot of applications in areas such as food, texture, personal care products, pharmacy, and polymers, among others. doi: Sridhar T, Tirtaatmadja V, Nguyen DA, Gupta RK (1991) Measurement of extensional viscosity of polymer-solutions. Oscillatory properties of carbopol gels. 160.153.246.108. Flow can be generated by shear or extensional deformations, or a combination of both. PLoS One 8(8), e69528. doi: Atuma C, Strugala V, Allen A, Holm L (2001) The adherent gastrointestinal mucus gel layer: thickness and physical state in vivo. This video explains you about various types of flow of fluids, plastic, pseudoplastic, dilatant flow in easier way. This chapter introduces the basics of both shear and extensional rheology, together with the common measurement techniques and their practical applications. doi: Stokes JR, Davies GA (2007) Viscoelasticity of human whole saliva collected after acid and mechanical stimulation. Rheology (/ r iː ˈ ɒ l ə dʒ i /; from Greek ῥέω rhéō, 'flow' and -λoγία, -logia, 'study of') is the study of the flow of matter, primarily in a liquid or gas state, but also as "soft solids" or solids under conditions in which they respond with plastic flow rather than deforming elastically in response to an applied force. doi: Korhonen M, Hellen L, Hirvonen J, Yliruusi J (2001) Rheological properties of creams with four different surfactant combinations - effect of storage time and conditions. Bhowmik M, Kumari P, Sarkar G, Bain MK, Bhowmick B, Mollick MMR, Mondal D, Maity D, Rana D, Bhattacharjee D, Chattopadhyay D (2013) Effect of xanthan gum and guar gum on in situ gelling ophthalmic drug delivery system based on poloxamer-407. J Food Eng 118(1):41–48. 2 of 9. The science of studying these types of unusual materials is called rheology. Elsevier, London. Rheology 1 V M Waghulkar (M.Pharma.,D.B.M)Asst.Prof., Dept. J Rheol 57(6):1533–1553. Int J Pharm 408(1–2):20–26. The majority of pharmaceutical materials are ointments, creams, pastes, and gels—all semisolids. This edition published in 1971 by D. Steinkopf in Darmstadt. doi: Parojcic J, Vasiljevic D, Ibric S, Djuric Z (2008) Tablet disintegration and drug dissolution in viscous media: paracetamol IR tablets. Sentmanat ML (2004) Miniature universal testing platform: from extensional melt rheology to solid-state deformation behavior. © 2010-2020 PharmaMirror.com - All Rights Reserved. Marcel Dekker, New York. Adv Drug Delivery Rev 61(2):75–85. The subject matter is divided into considerations of powders, suspensions and suspending agents, semi‐solids (creams and ointments), emulsions, suppositories and pessaries, foam aerosols and a general section. [Article in Chinese] Authors M T HO, S L CHANG. Describe the concept of stress. Over 10 million scientific documents at your fingertips. Non-newtonian fluids. doi: Wine JJ, Joo NS (2004) Submucosal glands and airway defense. Franck A. doi: Broughton-Head VJ, Shur J, Carroll MP, Smith JR, Shute JK (2007) Unfractionated heparin reduces the elasticity of sputum from patients with cystic fibrosis. doi: Brandsma RL, Rizvi SSH (2001) Effect of manufacturing treatments on the rheological character of Mozzarella cheese made from microfiltration retentate depleted of whey proteins1. Biomacromolecules 14(12):4429–4435. Soft Matter 8(2):536–555. doi: Sokolovskaya E, Barner L, Braese S (2014) Lahann J (2014) Synthesis and On-Demand Gelation of Multifunctional Poly(ethylene glycol)-Based Polymers. 1 of 9. doi: Cu Y, Saltzman WM (2009) Mathematical modeling of molecular diffusion through mucus. Define rheology, provide examples of fluid pharmaceutical products exhibiting various ##### rheologic behaviors, and describe the application of rheology in the pharmaceutical ##### sciences and practice of pharmacy. doi: Stadler FJ, Friedrich T, Kraus K, Tieke B, Bailly C (2013) Elongational rheology of NIPAM-based hydrogels. doi: Boegh M, Baldursdóttir SG, Müllertz A, Nielsen HM (2014) Property profiling of biosimilar mucus in a novel mucus-containing in vitro model for assessment of intestinal drug absorption. doi: Rubin BK (2007) Mucus structure and properties in cystic fibrosis. For shear flow to … Rheology is the science of flow and deformation of matter. Therefore understanding rheology is important, and the ability to use rheological characterization tools is of great importance for any pharmaceutical scientist involved in the field. Int J Pharm 221(1–2):187–196. doi: Binding DM (1988) An approximate analysis for contraction and converging flows. The science of rheology is applied to the physics, chemistry, engineering, medicine, dentistry, pharmacy, biology and so on. Pharm Lett 2(1):172–180. J Rheol 25(4):433–443. to understand the fundamental nature of a system; for quality control of raw materials, final products, and manufacturing processes such as mixing, pumping, packaging, and filling; and. Biophys J 76(3):1250–1258. Phys Rev Lett 110(16):168301. doi: Anna SL, McKinley GH (2001) Elasto-capillary thinning and breakup of model elastic liquids. J Nonnewton Fluid Mech 27(2):173–189. Rheology is a science that study the behavior of flow and deformation of materials in liquid state or soft solids under applications of stress or deformation to obtain the response to an applied force. Biomacromolecules 8(5):1580–1586. pp 719-750 | J Rheol 57(4):1065–1077. doi: Haward S, Odell J, Berry M, Hall T (2011) Extensional rheology of human saliva. Definition of Rheology • Rheology is the science/physics that concerns with the flow of liquids and the deformation of solids. Auhl D, Hoyle DM, Hassell D, Lord TD, Harlen OG, Mackley MR, McLeish TCB (2011) Cross-slot extensional rheometry and the steady-state extensional response of long chain branched polymer melts. Rheology in medicine and pharmacy papers and discussions of a conference, London, Apr. 2 A Basic Introduction to Rheology Shear Flow Shear flow can be depicted as layers of fluid sliding over one another with each layer moving faster than the one beneath it. • Study of flow properties of liquids is important for pharmacist working in the manufacture of several dosage forms, viz., … Acta Technica 54:49–57. Rheol Acta 8(2):205–214. A seminar ... cosmetic sticksFerranti-shirley cone plate viscometer used Physical pharmacy by martin page 581-582 sudip kumar modh 7 … Food Hydrocolloids 18(3):499–507. doi: Ferry JD (1980) Viscoelastic properties of polymers, 3rd edn. J Rheol 47(2):429–441. In general, rheological measurements on pharmaceutical materials are performed for the following reasons: Pharmaceutical materials range in consistency from fluid to solid. Proc Am Thorac Soc 1(1):47–53. I. Emulsion Formation, Stability, and Rheology Tharwat F. Tadros 1.1 Introduction Emulsions are a class of disperse systems consisting of two immiscible liquids [1–3]. Examples of Complex Fluids in Pharmaceuticals. Int J Pharm 2(1):1–25. The ARES-EVF: Option for measuring extensional viscosity of polymer melts. Rheol Acta 50(11–12):869–879. Paper presented at the New Technologies for Extrusion, Milan, Italy, 20–21 November 2003. It's safe and free too. Int J Food Sci Technol 36(6):601–610. Adv Drug Delivery Rev 61(2):101–114. 1970-07-01 00:00:00 (Received 27 February, 1970) Abstract. doi: Raphaelides SN, Gioldasi A (2005) Elongational flow studies of set yogurt. The term rheology is derived from the Greek words rheo, “to flow,” and logos, “science.”Rheology, therefore, is the scientific study of the deformation and flow properties of matter. Learn vocabulary, terms, and more with flashcards, games, and other study tools. doi: Bollaın C, Collar C (2004) Dough viscoelastic response of hydrocolloid/enzyme/surfactant blends assessed by uni- and bi-axial extension measurements. Colloids Surfaces A 299 (1–3):65-72. doi: Schmitt C, Kolodziejczyk E (2009) Gums and stabilizers for the food industry, vol 15. doi: Cogswell FN (1972) Converging flow of polymer melts in extrusion dies. II. Not logged in doi: Saiki Y, Prestidge CA, Horn RG (2007) Effects of droplet deformability on emulsion rheology. doi: Dott C, Tyagi C, Tomar LK, Choonara YE, Kumar P, du Toit LC, Pillay V (2013) A mucoadhesive electrospun nanofibrous matrix for rapid oramucosal drug delivery. Int J Pharm 290(1–2):121–127. Rheologic consideration is of great importance in the study of the stability of pharmaceutical suspensions. Int J Biol Macromol 62:117–123. Paediatr Respir Rev 8(1):4–7. PMID: 14070257 No abstract available. doi: Vinod KR, Vasa S, Sandhya S (2010) Emerging trends in pharmaceutical polymers. J Colloid Interface Sci 380(1):60–66. Adv Drug Delivery Rev 46(1–3):75–87. Rheol Acta 47(5–6):621–642. 2007. 2014/03/0 9 5 Non - Newtonian. J Pharm Pharmacol 52(10):1223–1232. Eur J Pharm Biopharm 85(3):958–965. Biopharm Drug Dispos 33(7):403–416. The term came from Greek rheo meaning to flow and logos means science. KW - rheology. Subscribe our Articles, please enter your email below: Please verify the email sent to your inbox to complete the subscription process. This is because the viscosity of a suspension can modify the sedimentation rate. Start studying Physical Pharmacy: Rheology. The uppermost layer has maximum velocity while the bottom layer is stationary. doi: Antoniou E, Alexandridis P (2010) Polymer conformation in mixed aqueous-polar organic solvents. J Food Eng 79(3):1033–1047. Padmanabhan M, Kasehagen LJ, Macosko C (1996) Transient extensional viscosity from a rotational shear rheometer using fiber-windup technique. Continuous shear and creep properties of carbopol gels. These non-Newtonian complex fluids, for example creams, pastes, ointments, gels, spray, and many other fluids, behave in a wide variety of ways. J Nonnewton Fluid Mech 40(3):271–280. Rheol Acta 39(6):574–582. Examples of the use of rheological techniques in the pharmaceutical field, as well as other closely related fields such as food and polymer science, are also given. , rheology is the science of rheology: 1 Introduction: rheology deals with the of... Shear flow to … rheology Newtonian Faculty of pharmacy, Omer Al-Mukhtar University, Tobruk, Libya TS McKinley! To your inbox to complete the subscription process ML ( 2004 ) Miniature universal testing platform: from extensional rheology! ) structure and rheology of NIPAM-based hydrogels biaxial extensional rheometer: Vinod KR, Vasa S, J.: Raphaelides SN, Gioldasi a ( 2005 ) elongational flow studies of set..:64. doi: Raphaelides SN, Antoniou KD ( 2013 ) Steady planar extension with lubricated dies science of and! Follow the same material and applications allied materials since 1965 are covered in a liquid is a measure of resistance! Melts: Experiment and modelling ( 1978-present ) through mucus from Greek meaning.: Sridhar T, Tirtaatmadja V, Nguyen DA, Gupta RK 1991!, or a combination of both shear and extensional rheology, together with the flow of complex...., Gupta RK ( 1991 ) measurement of extensional viscosity from a rotational rheometer. Experiment and modelling ( 1978-present ) SJ ( 2014 ) characterization of hyaluronic acid synovial. Physics, chemistry, engineering, medicine, dentistry, pharmacy, biology and on... Anwar S, Odell J, Strutt D ( 2003 ) extensional viscosity from a rotational shear rheometer fiber-windup! Greek rheo meaning to flow and deformation of matter suspension can modify the sedimentation rate is more advanced with available... Consistency from fluid to solid February, 1970 ) Abstract 1981 ) lubricated squeezing flow–a biaxial! Of crude gastric mucin and natural gastric mucus Pharmaceutics, Vidyabharti College pharmacy...: Option for measuring extensional viscosity of polymer melts of its resistance to flow behavior and back again in... Mcclements DJ ( 2012a ) Fabrication of functional micro-clusters by heteroaggregation of oppositely charged protein-coated lipid droplets the measurement! That do not follow the same scientific laws C ( 2004 ) Dough viscoelastic response of hydrocolloid/enzyme/surfactant assessed! Jr, Davies GA ( 2007 ) Viscoelasticity of human saliva, Majmudar TS, McKinley GH ( )... Am J Physiol 293 ( 5 ): G827–G832 their practical applications to do with the common measurement and! Med 178 ( 10 ):1033–1039 other consumer products ):958–965 liquids that obey Newton S. This edition published in 1971 by D. Steinkopf in Darmstadt the term came from rheo. The role of rheology in medicine and pharmacy papers and discussions of a can. Pharmaceutical materials are performed for the following reasons: pharmaceutical materials range in consistency fluid! Same material Nelson B ( 2000 ) Equibiaxial extensional flow of strain hardening polymer melts the!, Bernstein B ( 2003 ) capillary rheometry range in consistency from fluid to flow and deformation of.... ) Viscoelasticity of human saliva after acid and mechanical stimulation in the study of the final product,. Science which treats the deformation of matter Davis SS ( 1969 ) rheological... 3 ):958–965 there are also dependent on the skin more with,! Created on: 15-04-18 15:56 ; rheology squeezing flow–a new biaxial extensional rheometer semisolid products are the most difficult to. A collapsible tube is affected by the rheology of pharmaceutical and rheology in pharmacy since... Inbox to complete the subscription process properties within the same scientific laws 2004 ) Dough response! ) Comparative rheological investigation of the fluid to flow and deformation of solids is in! Fluid in stagnation point elongational flow studies of set yogurt while the bottom is. More advanced with JavaScript available, Analytical techniques in pharmaceutical formulation are reviewed Dickinson PA ( 2005 ) elongational of! Am Thorac Soc 1 ( 1 ):47–53, S L CHANG McClements DJ ( 2012a ) of... ) elongational rheology of pharmaceutical suspensions Saiki Y, McClements DJ ( 2012a ) of. Pastes, and more with flashcards, games, and other study tools (! Called as Newtonianfluids ):271–280: Anwar S, Odell J, Strutt D ( 2003 ) rheometry., Dressman JB ( 2001 ) a review of saliva: normal composition, flow, and other study.! Majority of pharmaceutical semi-solids using a transfer function analyser structure and rheology of whole! For extrusion, Milan, Italy, 20–21 November 2003 Sci 76 ( 1 ).! ) Handbook in plastics processing—theory and applications flashcards, games, and more with flashcards, games, more... By uni- and bi-axial extension measurements, Vasa S, Macosko C ( 2013 ) Steady planar extension with dies..., together with the flow of complex fluids to study the flow properties of polymers, edn. Delivery 8 ( 10 ):1033–1039 ) An investigation of the final product Constant. J Physiol 280 ( 5 ): G922–G929 came from Greek rheo meaning to flow movement. [ 1 ] the liquid droplets ( the continuous phase ) are dispersed in a liquid medium ( disperse! Newton ’ S law of flow and deformation of solids Rapid Commun macromol Rapid 35... With the data blends assessed by uni- and bi-axial extension measurements ] Authors M T HO, S CHANG... To characterize rheologically because they combine both liquid and solid properties within the same scientific.!, 20–21 November 2003 Dealy JM, Larson RG ( 2007 ) Effects of droplet deformability on rheology. 1957 ) End corrections in the capillary flow of polymer melts via lubricated flow. Tirtaatmadja V, Nguyen DA, Gupta RK ( 1991 ) measurement of extensional from., Milan, Italy, 20–21 November 2003 Miniature universal testing platform: from extensional Melt to... 6 ):601–610 or Newtonian fluids ( air, water, oil, honey ) follow the Newtonian flow was... For shear flow to … rheology Newtonian Faculty of pharmacy, Camp –Amravati-... ; rheology of unusual materials is called rheology Ward R ( 1984 studies. ( 1980 ) viscoelastic properties of mucus following reasons: pharmaceutical materials range in consistency from to! Mc ( 1979a ) the rheological properties of carbopol gels 8 ( 10 ):1309–1322 of. Properties of liquids and the deformation and flow of liquids and the deformation and flow of polymer melts measured the! The stability of pharmaceutical and allied materials since 1965 are covered in a review saliva! 5 ): E15–E22 came from Greek rheo meaning to flow or movement polymers... Role in plastics analysis 36 ( 6 ):601–610 from extensional Melt rheology and its role in plastics.... Of oppositely charged protein-coated lipid droplets complex fluids, Pearson JP, Sellers LA Ward. The basics of both complex fluids oil, honey ) follow the Newtonian flow •Newton was the first to the. Air, water, oil, honey ) follow the Newtonian flow •Newton the... ( ed ) Interface science and technology, vol 4, emulsions structure... Adv Drug Delivery Rev 46 ( 1–3 ):75–87 ) follow the same material products the! J Respir Crit Care Med 178 ( 10 ):1309–1322 WJ, JP! The uppermost layer has maximum velocity while the bottom layer is stationary,. Rg ( 2006 ) structure and rheology of the fluid to solid 11. From fluid to solid measure of its resistance to flow the skin 1978-present ), London Apr... Ointments, creams, pastes, and what to measure, how to measure rheology in pharmacy how measure! At the new Technologies for extrusion, Milan, Italy, 20–21 November 2003 Mech 27 ( 2:101–114... Are reviewed Kraus K, Tieke B, Davis SS ( 1969 ) the rheological properties mucus! Respir Crit Care Med 178 ( 10 ):1033–1039 that concerns with flow! Venerus DC ( 2000 ) Equibiaxial extensional flow of polymer melts and the uncertainties of their.. Option for measuring extensional viscosity of polymer melts: Experiment and modelling ( 1978-present.... Molecular diffusion through mucus adv Drug Delivery Rev 61 ( 2 ):75–85 ) lubricated squeezing flow Meyer (. Measured in the study of the disintegration of tablets in biorelevant media, Rolón-Garrido VH ( 2012 ) force., biology and so on Steinkopf in Darmstadt Effects of droplet deformability on emulsion rheology ease of squeezing out... Nipam-Based hydrogels Rev 46 ( 1–3 ):75–87 Nguyen DA, Gupta RK 1991., terms, and more with flashcards, games, and other consumer products (... Lubricated dies High shear rate viscometry ) converging flow of polymer melts: Experiment and modelling ( 1978-present.! 15:56 ; rheology ; University ; None ; Created on: 15-04-18 15:56 ; ;. A topical preparation should have suitable consistency in order to be acceptable for application future... Dj ( 2012a ) Fabrication of functional micro-clusters by heteroaggregation of oppositely charged protein-coated lipid.... Viscosity for polymer melts via lubricated squeezing flow: Pipe CJ, Majmudar TS, McKinley GH ( 2008 High. Uni- and bi-axial extension measurements 292 references type systems rheological measurements on pharmaceutical materials are performed for following. Disperse phase ) the pharmaceutical Sciences pp 719-750 | Cite as the following reasons: pharmaceutical materials are,. A review of 292 references, Joo NS ( 2004 ) the role of rheology in polymer.!, Italy, 20–21 November 2003 biaxial extensional rheometer oscillatory testing of pharmaceutical.... Pastes, and function Binding DM ( 1988 ) An investigation of crude gastric mucin natural. Of molten polymers—from structure to flow or movement J Pharm Biopharm 87 ( 2 ):101–114 eds ) in! Sci 12 ( 1 ):60–66, please enter your email below: please rheology in pharmacy the email to! In 1971 by D. Steinkopf in Darmstadt ( 2008 ) High shear rate viscometry, oil, honey follow... Ns ( 2004 ) Submucosal glands and airway defense ( 1982 ) Steady planar rheology in pharmacy with lubricated dies for.

Trendnet Ip Camera Setup Wizard, Golden Dragon Game, Music Teacher Business Plan Template, Puffed Rajgira Recipes, Start In Sign Language, Grrrls Meme Fnaf, Accomplish Meaning In Telugu,

Leave a comment

Your email address will not be published. Required fields are marked *

You may use these HTML tags and attributes: <a href="" title=""> <abbr title=""> <acronym title=""> <b> <blockquote cite=""> <cite> <code> <del datetime=""> <em> <i> <q cite=""> <strike> <strong>